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Direct Preventive Care

What Happens If You Take Sildenafil and Tadalafil Together



Erectile dysfunction is an issue that affects millions of men worldwide. In most cases, the use of various drugs such as sildenafil, also commonly referred to as Viagra, and tadalafil, also commonly referred to as Cialis, will also follow because these two medications are highly effective in treating ED, but they have different methods and durations. This raises the question: what happens if you take sildenafil and tadalafil together?

In this blog, we will explain the mechanism of action for both drugs, discuss safety when combining them, and look at potential side effects. We will also learn if combining sildenafil and tadalafil may often be evocative when kept under specified conditions to arm you with the right information for making safe choices. 

How Do Sildenafil And Tadalafil Work? 

Essentially, sildenafil and tadalafil fall in the category of drugs referred to as phosphodiesterase type 5 (PDE5) inhibitors. While these drugs may work slightly differently, they both are PDE5 inhibitors that will restrict blood flow to the penis. On blocking the PDE5, both sildenafil and tadalafil increase the blood flow to help achieve and maintain erections for men. 

Since its discovery, sildenafil is typically taken one hour before sexual activity and will last for approximately 4-6 hours. Tadalafil, as you know, lasts longer and stays active for up to 36 hours. Tadalafil can be administered once a day, and this leaves more time for spontaneous sexual activity. 

What Happens If You Take Sildenafil and Tadalafil Together? Can You Mix Sildenafil and Tadalafil? 

The most frequently asked question by men is – what happens if you take sildenafil and tadalafil together? You might expect that the combination of the two would increase their effects, but it is strictly not advisable to take both drugs at once. That is not because it would lead to severe adverse reactions but rather simply due to the fact that the two drugs belong to the same class and act in essentially the same way: they relax blood vessels and increase blood flow. Its two formulations may produce some serious side effects, such as hazardous hypotension. 

What Happens If You Take Sildenafil and Tadalafil Together


In reality, the situation may be aggravated instead of improved without professional help. Some men might think that a low dose of tadalafil will be enough to work for a long time and, therefore. You may use it by taking sildenafil when you need a quick boost. Prior knowledge of the impacts is essential when you think – can you mix sildenafil and tadalafil medications. 

What Happens If You Take Sildenafil and Tadalafil Together? 

So, what happens if you take sildenafil and tadalafil together? So, this dangerous synergy of the two drugs can lead to: 

  • Low Blood Pressure: Both the blood pressure drops caused by the two drugs can get very severe, causing dizziness or fainting and even cardiac complications. 
  • Risk of side effects: Headaches, indigestion, and muscle pain are some of the common PDE5 inhibitor-related side effects that can become more severe in combination with these two drugs. 
  • Priapism: One of the most severe side effects connected with tadalafil is priapism – a long and painful erection that persists for several hours. This condition may lead to permanent damage to the penis if not treated. 
  • Dizziness and Syncope: The simultaneous action of both drugs is likely to cause dizziness and syncope, especially when they are administered in combination with other drugs, such as nitrates or alpha-blockers. 

Although the benefits of these drugs are plentiful if taken correctly. What happens if you take sildenafil and tadalafil together? The risk of the combination is much more than the potential benefits. 

When Can Sildenafil and Tadalafil Be Taken Together? 

There are extremely few cases where both drugs, sildenafil and tadalafil, may be used together. Some very rare cases exist where compounded medication with low doses of both drugs is prescribed by doctors for specific patient requirements. Strictly conducted under the surveillance of a medical professional, even then, the dosages for each drug are calibrated in such a way that helps to avoid side effects. 

People react differently when using both sildenafil and tadalafil together, so this might vary with age, medical history, and other medicines available. However, it is always best to ask your doctor for advice before trying a combination of these drugs. 



Safer Alternatives to Combining Sildenafil and Tadalafil 

But can you mix sildenafil and tadalafil? There are safer alternatives that don’t call for combining the drugs. Here are some of them: 

Alternate Between Medications: In lieu of taking both drugs at once, some men alternate between them, depending on the situation. For instance, a man might take sildenafil for short-term use since it is known to be effective and lasts longer, or he can use tadalafil because it lasts much longer. 

Tadalafil Daily: For patients who are not interested in having to try to time their medication, daily dosing of tadalafil allows for a steady improvement in blood flow without having to take the additional dose. 

Lifestyle Changes: Most men will derive lifestyle alterations in diet, exercise, and stress management to greatly improve their response to ED medication. Reductions in alcohol consumption, smoking and alleviation of stress factors are very simple ways patients can facilitate relief from the symptoms of ED without a mix-and-match prescription package. 

The doctor may offer the patient consultation based on his medical history to alter dosages or other modes of treatment of ED. In other instances, the cause of ED will require antidotes to administration, like in low levels of testosterone or managing diabetes. 

Risks of Self-Medicating with ED Drugs 

Can you mix sildenafil and tadalafil? While it may seem appealing to combine sildenafil and tadalafil to amplify the effect of ED medications, self-medication can be fatal without professional advice. This will lead to further side effects, which might even prove dangerous, and the underlying health condition gets covered up and not taken care of. More often than not, erectile dysfunction is indicative of a critical medical problem, heart disease, for example, or a hormonal disorder that needs evaluation by a physician. 

Another risk factor, which may be buying prescription-only ED medications from rogue online pharmacies or using street drugs, will be avoided. Be sure to use only genuine ED drugs authorized by the FDA from reputable providers so as not to consume harmful duplicate or fake products. 

Seek Professional Help for ED Treatment 

If you plan to undergo ED treatment, talk to your doctor first. While both sildenafil and tadalafil are powerful drugs, can you mix sildenafil and tadalafil? You should not mix the two without a consultation.  Well, for that, it is best left up to your doctor, who can judge your specific situation and provide the right course of treatment for you.  

If you still face ED and do not like the therapy with the help of pills, then it’s open to see a doctor. A doctor will be able to analyze your problem and provide an effective course of treatment, ensuring that it’s safe. What happens if you take sildenafil and tadalafil together remains unpredictable; however, being guided by a medical doctor will help ensure treatment is safe. 

Finding Affordable ED Medications at Direct Preventive Care  

A significant number of men find it hard to manage the price of ED drugs. However, with Direct Preventive Care, there are affordable and effective solutions available. For men in need of sildenafil, Direct Preventive Care has Sildenafil, a generic version of Viagra that delivers stronger and longer-lasting erections at up to 95 percent less than the branded counterpart. So, with Direct Preventive Care, men can have drugs prescribed by their doctor without blowing holes in their wallets.

For those researching tadalafil, Direct Preventive Care offers a non-branded equivalent of Cialis at the same cost. With Tadalafil, men can gain near-instant access to healthcare providers within a 24-hour window, ensuring that they receive what they need without unnecessary delay.  Let’s get started and consult our expert physicians for the safest ED treatment and explore affordable options at Direct Preventive Care.

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